Type of Enzyme
Applications
In the Public Domain since
June 11, 2012
Application Features
Sulfolobus DNA Polymerase IV is a thermostable Y-family lesion-bypass DNA Polymerase
Efficiently synthesizes DNA across a variety of DNA template lesions
Can be used for DNA repair
Original Paper
Pisani, F. M., Martino, C. D., & Rossi, M. (1992). A DNA polymerase from the archaeon Sulfolobus solfataricus shows sequence similarity to family B DNA polymerases. Nucleic acids research, 20(11), 2711-2716.
Boudsocq, F., Iwai, S., Hanaoka, F. and Woodgate, R., 2001. Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic polĪ·. Nucleic acids research, 29(22), pp.4607-4616. https://doi.org/10.1093/nar/29.22.4607
- DNA Sequence (optimised & domesticated)